MedClips

Long-term treatment results of hepatoblastoma at a single institution in Taiwan. Hou JY, Liu HC, Yeh TC, Chen SH, Wang LY, Sheu JC, Liang DC. PMID: 19727010 From 1990 to 2004, 23 patients with Hepatoblastoma were treated at the Mackay Memorial Hospital in Taipei. The basic information of each person is summarized in table 1, and in addition to the surgery, the first line therapy was cisplatin 90 mg / m 2 / d on the first day and epirubicin 25 mg / m 2 / d on the first day to the third day. Each course was repeated every 3 weeks and Epirubicin was chosen because of its low cardiotoxicity. Carboplatin / etoposide, vincristine / cyclophosphamide / 5-fluorouracil were used as secondary agents when the cumulative toxicity of the first-line treatment became a problem. Table 2 lists information about the medicines used to treat people and their current disease status. In the first case of immediate surgical removal, 4-6 courses of post op chemotherapy were performed, of which 3 died due ...

Hepatoblastoma in children with Beckwith-Wiedemann syndrome: does it warrant different treatment? Trobaugh-Lotrario AD, Venkatramani R, Feusner JH. PMID: 24608075 In this paper, we analyzed the cases with hepatoblastoma among 56 BWS patients. Patients with Beckwith-Wiedemann Syndrome (BWS) are 2,000 times more likely to get hepatoblastoma than the average population. At the time of diagnosis of hepatoblastoma, the mean age of the patients was 6 months. Of the 26 patients, 13 were born premature. Of 31 patients, 19 had hemihypertrophy and 32 of 33 had AFP levels at diagnosis. The overall survival rate was about 75%, of which 27 out of 36 survived. Of the 25 survivors, 24 received chemotherapy and surgery. All 9 patients who had undergone routine liver cancer screening were all alive until the time of the report, suggesting a prospective study of whether BWS patients will be regularly screened for further survival after early detection.

Long-term recurrence of bile duct stones after endoscopic papillary large balloon dilation with sphincterotomy: 4-year extended follow-up of a randomized trial. Paspatis GA, Paraskeva K, Vardas E, Papastergiou V, Tavernaraki A, Fragaki M, Theodoropoulou A, Chlouverakis G. PMID: 27317037 In this paper, we investigated the long-term outcome of endoscopic papillary large balloon dilation (EPLBD) and endoscopic biliary sphincterotomy (EBS) in the treatment of CBD stone, 30s vs. 60s ballon dilation comparison trial) was followed by extended follow-up (4 years). Among other studies, CBD stone recurred in about 11% of long-term cases with EBS only. Prospective follow-up showed that the prevalence of previous cholecystectomy was 7.5% in 106 patients and 51% in patients who had received EBS before. Of these patients, 8 of 106 patients with a recurrent CBD stone showed a 7.5% dml ratio and the median baseline diameter was significantly longer than those without recurrence. Discussion of thi...

Hyponatremia in cirrhosis: pathophysiology and management. John S, Thuluvath PJ PMID: 25805925 Hyponatremia is frequently accompanied by ascites or portal hypertension as a complication of advanced liver cirrhosis. Although ascites do not appear in the early stages, cirrhosis progresses and ascites leads to kidney damage by eliminating solute-free water, which causes water retention due to compensatory mechanisms such as non-osmotic secretion of ADH (eg arginine vasopressin) Hyponatremia will occur. In patients with cirrhosis, hyponatremia increases morbidity and mortality and is an important prognostic factor before and after liver transplant. In this case, conventional therapy for hyponatremia is fluid restriction and loop diuretics, but it is often inefficacious, and this paper deals with pathophysiology and various treatments. In this paper, hyponatremia in patients with cirrhosis is the main indication of correction, with serum sodium below 120 and hyponatremia with neurologi...

Primary dysmenorrhea magnitude, associated risk factors, and its effect on academic performance: evidence from female university students in Ethiopia. Hailemeskel S, Demissie A, Assefa N PMID: 27695366 Primary dysmenorrhoea is the most common gynecological condition for adolescent women and is the leading cause of adolescent women falling into work or school. The purpose of this study was to analyze the risk factors associated with the prevalence of primary dysmenorrhea and to understand the impact of primary dysmenorrhea. This study is an analysis of 440 students. Of the 440 students, 368 and 85.4% of the students complained of primary dysmenorrhea, 123 of them, 28.5% of mild pain, 164 of them, 38.1% of moderate pain, 81 of them, severe of 18.8% The patient complained of primary dysmenorrhea. Of the students appealing for dysmenorrhoea, 88.3% said that dysmenorrhea had a negative impact on their academic performance, with 80% of them having absences and 66.8% of th...

Dental treatment in patients with leukemia. Zimmermann C, Meurer MI, Grando LJ, Gonzaga Del Moral JÂ, da Silva Rath IB, Schaefer Tavares S. PMID: 25784937 Neutrophil and platelet counts play a major hematologic index in predicting bleeding, infection risk, and whether to perform dental procedures. There are no internationally accepted protocols, but several recommendations have been published. (Table 2) Generally, antibiotic prophylaxis is required when the neutrophil count is less than 1,000 cells / mm3, and transfusion is recommended when the platelet count is 40,000-60,000 cells / mm3. Dental procedures can be divided into six groups according to the degree of invasiveness. Types I and II are noninvasive procedures, and patients can be enrolled at any time before, during, and after chemotherapy. In this case, the patient is in the transchemotherapy group because of the fact that the consolidation therapy will be started immediately after the induction therapy 2 weeks after th...

CNI withdrawal for post-transplant lymphoproliferative disorders in kidney transplant is an independent risk factor for graft failure and mortality. Rabot N, Büchler M, Foucher Y, Moreau A, Debiais C, Machet MC, Kessler M, Morelon E, Thierry A, Legendre C, Rivalan J, Kamar N, Dantal J. PMID : 24964147 Post-transplant lymphoproliferative disorder (PTLD) is not a common complication after transplantation, so prospective studies have been conducted mainly because it is difficult to perform prospective studies. PTLD is mostly a B cell origin and may be associated with EBV. PTLD can occur if the patient's immune system does not respond well to EBV infection. In this study, we investigated the effect of PTLD on the survival of patients and grafts after complete termination of the calcineurin inhibitor (CNI) in kidney transplant recipients. Patients were selected according to the criteria selected in the study, and follow-up was carried out after diagnosis of PTLD. When the cu...