Inflammatory myopathy(dermatomyositis and polymyositis): Issues with malignancy
Dermatomyositis and polymyositis are inflammatory myopathies with symptoms of proximal muscle weakness and muscle inflammation. Unlike PM, DM also includes multiple skin lesions. They are often accompanied by other rheumatic diseases. First, the pathophysiology of inflammatory myopathy is not completely understood. However, there is a relationship between inflammatory myopathy and cancer in several patients. In myositis - persistent muscle tissue, a higher concentration of myositis - specific autoantibodies is secreted by other common muscle tissues. These autoantibodies are known to be present at high concentrations in various types of cancers that are known to be associated with myositis. These observations suggest that there are autoantibodies common to diseases such as PM, DM, and cancer, and antibodies targeting tumor tissues can also cause muscle damage. The types of cancer that are associated with inflammatory myositis include ovarian cancer, cervical cancer, lung cancer, panc...