MedClips

Symptoms Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organs. The immune complex formed by autoantibody and autoantigen binds to various organs such as joints, skin, kidneys, and CNS and causes inflammation. The prevalence rate is high.  In most SLE patients, fatigue, fever, myalgia, and weight loss are present. In addition, there are other cutaneous lesions such as cutaneous lesions, oral or nasal ulcers, vascular disease (Raynaud phenomenon, Vasculitis, Thromboembolic disease ), Nephritis, GI symptoms (adverse medication reactions or infections), pleuritis, and life threatening diseases such as pericarditis. Diagnosis  SLE can be diagnosed according to the 2012 SLICC criteria. 11 clinical and 6 immunologic criteria, at least one criterion is met and more than 4 of 17 criteria are met. Clinical criteria include Acute cutaneous lupus, Chronic cutaneous lupus, Nonscarring alopecia, Oral or nasal ulcer, Joint disease, Serositis, Renal, Neur...

SLE eliminates other diseases and diagnoses based on the judgment of an experienced doctor who knows the characteristic clinical symptoms. This approach can be difficult to diagnose because of the wide variety of SLE clinical manifestations. Currently, there is no SLE diagnostic criteria. However, SLE diagnosis is approached by referring to '2012 SLICC classification criteria' and '1997 ACR classification criteria' that classified SLE for the study. According to the 2012 SLICC criteria, SLEs must meet four or more of the 17 criteria (one must meet one of 11 clinical criteria and one must be one of six immunological criteria) A SLE characteristic antibody (ANA, anti-dsDNA) can be detected in the blood and diagnosed when there is a confirmed lupus nephritis by a kidney biopsy. However, even if you do not meet this criterion, you may suspect SLE when you are satisfied with '2 or 3 out of 17 + one or more related symptoms that are not SLE-specific'. Because the sym...