Retroperitoneal fibrosis: Symptoms, Pathogenesis, Work-ups & Treatments
Symptoms Retroperitoneal fibrosis is one of the IgG4-related disease (IgG4-RD) with increased IgG4 antibody and is a disease in which retroperitoneum fibrosis occurs over the fourth and fifth lumbar spine. It is characterized by the appearance of retroperitoneal structures, especially ureteral stenosis. The symptoms of retroperitoneal fibrosis are nonspecific, and patients present with symptoms such as dorsal non-colicky pain, fever, weight loss, and nausea. Pathogenesis The pathogenesis of IgG4-related disease is still unclear. Although IgG4-RD has been detected in patients with diseases, the name IgG4-RD has emerged, but it is still unclear whether the IgG4 antibody is pathogenic. There is also a hypothesis that an increase in IgG4 is a downward process of other more important processes. The characteristics of IgG4 related disease are autoimmune and allergic. Autoimmune aspects include autoantibodies to antigens such as lactoferrin and carbonic anhydrase in type-1 autoimmune panc...