Hyponatremia in cirrhosis: pathophysiology and management.
Hyponatremia in cirrhosis: pathophysiology and management. John S, Thuluvath PJ PMID: 25805925 Hyponatremia is frequently accompanied by ascites or portal hypertension as a complication of advanced liver cirrhosis. Although ascites do not appear in the early stages, cirrhosis progresses and ascites leads to kidney damage by eliminating solute-free water, which causes water retention due to compensatory mechanisms such as non-osmotic secretion of ADH (eg arginine vasopressin) Hyponatremia will occur. In patients with cirrhosis, hyponatremia increases morbidity and mortality and is an important prognostic factor before and after liver transplant. In this case, conventional therapy for hyponatremia is fluid restriction and loop diuretics, but it is often inefficacious, and this paper deals with pathophysiology and various treatments. In this paper, hyponatremia in patients with cirrhosis is the main indication of correction, with serum sodium below 120 and hyponatremia with neurologi...