MedClips

Symptoms Polymyositis is one of the idiopathic inflammatory myopathies characterized by proximal muscle weakness and muscle inflammation. Polymyositis is caused by cell mediated immunity due to endomysial infiltration of T cells, and thus an immune response is produced by CD8 + T cells. Clinical manifestations may vary depending on which autoantibody is involved in the disease and in which environment. The most common symptom is proximal muscle weakness or associated myalgia and muscle tenderness, as well as interstitial pulmonary disease (more frequently when anti-synthetase Ab is present), dysphagia due to esophageal muscle weakness, polyarthritis, Raynaud phenomenon symptoms May appear. Sometimes systemic sclerosis or systemic rheumatic disease features such as systemic lupus erythematosus are combined. Polymyositis is less common than dermatomyositis, but it also increases the risk of malignancy. When combined with anti-synthetase syndrome, a palmar of the finger, a mechanical han...

Diagnosis Creatine kinase (CK) is the most sensitive enzyme in the diagnosis of inflammatory myopathy among serum muscle enzymes. If the disease is active, it can increase up to 50 times normal. Generally, CK levels are proportional to disease activity, and SGOT, SGPT, LDH, and adolase are also increased. In PM, inflammation is the primary factor. T cells mainly infiltrate into the muscle bundles, surrounding normal muscle cells individually, and eventually muscle fiber necrosis and predation. MHC-I molecules are scattered in the sarcolemma, which increases the expression of MHC-I molecules in muscle fibers that are not infiltrated into CD8 + cells. The CD8 / MHC-I molecule lesion is the most essential finding in establishing the diagnosis and is a helpful finding in excluding the secondary non-specific inflammatory muscle disease. If the disease is chronic, connective tissues increase and may react positively to alkaline phosphate Inflammatory myopathy is characterized by an increa...

Dermatomyositis and polymyositis are inflammatory myopathies with symptoms of proximal muscle weakness and muscle inflammation. Unlike PM, DM also includes multiple skin lesions. They are often accompanied by other rheumatic diseases. First, the pathophysiology of inflammatory myopathy is not completely understood. However, there is a relationship between inflammatory myopathy and cancer in several patients. In myositis - persistent muscle tissue, a higher concentration of myositis - specific autoantibodies is secreted by other common muscle tissues. These autoantibodies are known to be present at high concentrations in various types of cancers that are known to be associated with myositis. These observations suggest that there are autoantibodies common to diseases such as PM, DM, and cancer, and antibodies targeting tumor tissues can also cause muscle damage. The types of cancer that are associated with inflammatory myositis include ovarian cancer, cervical cancer, lung cancer, panc...