Long-term treatment results of hepatoblastoma at a single institution in Taiwan.
Long-term treatment results of hepatoblastoma at a single institution in Taiwan.
Hou JY, Liu HC, Yeh TC, Chen SH, Wang LY, Sheu JC, Liang DC.
PMID: 19727010
From 1990 to 2004, 23 patients with Hepatoblastoma were treated at the Mackay Memorial Hospital in Taipei. The basic information of each person is summarized in table 1, and in addition to the surgery, the first line therapy was cisplatin 90 mg / m 2 / d on the first day and epirubicin 25 mg / m 2 / d on the first day to the third day. Each course was repeated every 3 weeks and Epirubicin was chosen because of its low cardiotoxicity. Carboplatin / etoposide, vincristine / cyclophosphamide / 5-fluorouracil were used as secondary agents when the cumulative toxicity of the first-line treatment became a problem. Table 2 lists information about the medicines used to treat people and their current disease status. In the first case of immediate surgical removal, 4-6 courses of post op chemotherapy were performed, of which 3 died due to disease progression / infection / recurrence respectively. The 20-year survivors had an average life expectancy of 94 months and a 5-year event-free and overall survival rate of 73.9% ± 9.2% / 87% ± 7.0%. Cancer recurrence was seen in 5 patients and neutropenia side effects were most frequent. No cardiotoxicity was seen in all. In conclusion, the combination of surgery and chemotherapy resulted in good hepatoblastoma treatment results. For treatment records for each patient, please refer to the article.
Hou JY, Liu HC, Yeh TC, Chen SH, Wang LY, Sheu JC, Liang DC.
PMID: 19727010
From 1990 to 2004, 23 patients with Hepatoblastoma were treated at the Mackay Memorial Hospital in Taipei. The basic information of each person is summarized in table 1, and in addition to the surgery, the first line therapy was cisplatin 90 mg / m 2 / d on the first day and epirubicin 25 mg / m 2 / d on the first day to the third day. Each course was repeated every 3 weeks and Epirubicin was chosen because of its low cardiotoxicity. Carboplatin / etoposide, vincristine / cyclophosphamide / 5-fluorouracil were used as secondary agents when the cumulative toxicity of the first-line treatment became a problem. Table 2 lists information about the medicines used to treat people and their current disease status. In the first case of immediate surgical removal, 4-6 courses of post op chemotherapy were performed, of which 3 died due to disease progression / infection / recurrence respectively. The 20-year survivors had an average life expectancy of 94 months and a 5-year event-free and overall survival rate of 73.9% ± 9.2% / 87% ± 7.0%. Cancer recurrence was seen in 5 patients and neutropenia side effects were most frequent. No cardiotoxicity was seen in all. In conclusion, the combination of surgery and chemotherapy resulted in good hepatoblastoma treatment results. For treatment records for each patient, please refer to the article.
