Kawasaki disease: Symptoms & Treatments

Symptoms
Kawasaki disease is an acute vasculitis that often occurs in young children. When left untreated, coronary aneurysm is known to occur in about 20% of patients. The exact cause of Kawasaki disease has not yet been elucidated, and there is a hypothesis that patients with genetic predisposition, especially those with Asians, are more likely to develop Kawasaki disease. There are characteristic clinical findings, which are diagnostic criteria. First, there is a high fever lasting more than five days. Palms or soles swollen and red. There are rashes of various shapes and sizes in the skin and itchy. Bilateral conjunctival hyperemia is seen, but there is no glare. There may be flushing and cracking of the lips, bleeding, and redness in the strawberry and oral mucous membranes. Cervical lymph node enlargement may also be seen.

Treatments
IVIg and aspirin are mainly used for treatment. High-dose aspirin and IVIg are given to the acute phase. When the fever completely falls from 48 to 72 hours, the dose of aspirin is lowered. Reye syndrome has been reported in patients receiving high dose aspirin over a long period of time, but it is not known to be a problem at low doses. IVIg is administered over a period of 10 to 12 hours with a high dose (2 g / kg) within 7 days of the first outbreak. With Giant aneurysm, warfarin and low dose aspirin prevent thrombosis.

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