Jaundice: Causes

Jaundice can be roughly divided into two groups: jaundice by unconjugated bilirubin and jaundice by conjugated bilirubin. Unconjugated bilirubin in the case of jaundice due to congenital abnormality, due to the failure of conjugation, or due to the overproduction of bilirubin itself occurs. Patients who can be encountered in the internal medicine department of the digestive organ are mainly patients who complain of jaundice due to conjugated bilirubin. Conjugated bilirubin - induced jaundice is divided into obstructive jaundice due to biliary tract obstruction and hepatocellular jaundice due to intrahepatic cause.
Obstruction jaundice shows an increase in both direct and indirect bilirubin, and characteristically shows increased alkaline phosphatase. Obstruction occurs, and even drainage does not occur, resulting in inflammation of the liver and mild elevation of OT / PT. Diseases that cause biliary tract obstruction are diverse. Biliary tract obstruction occurs due to primary sclerosing cholangitis (PSC), parasitic infections, or the like, which occurs around the bile duct, not in the bile duct, or in the bile ducts of the bile duct, cholangiocarcinoma, Of elevation and jaundice symptoms.
On the other hand, Hepatocellular jaundice usually shows elevated OT / PT and elevated mild elevation of ALP. The most common causes are hepatitis, alcoholic hepatitis, nonalcoholic steatohepatitis, primary biliary cholangitis, malignancy, total parenteral nutrition, liver transplantation, and drug or toxic agents.

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