Endometriosis: Treatments
Medical treatment of endometriosis
Medical treatment of endometriosis includes NSAIDs, hormonal contraceptives, GnRH agonists, danazol, and aromatase inhibitors. The choice of treatment depends on the severity of the symptoms, the patient's preference, the side effects of the drug, and the efficacy of the treatment.
NSAIDs NSAIDs are effective treatments for menstrual overeating. It is also often used as a primary treatment for pelvic pain. However, NSAIDs do not have a higher efficacy in treating pain due to endometriosis than other agents.
Estrogen-progestin contraceptives Complex contraceptives are used as a primary treatment for endometriosis-related pain because they are long-lasting, relatively cheap, and easy to use. It is often used because it has the effect of lowering the risk of ovarian cancer and endometrial cancer. Combination contraceptives inhibit the function of the ovary, thereby reducing the activity of endometriosis and reducing pain.
GnRH agonist GnRH agonist is known to be more effective than placebo, and it is known that pain relief is greater than danazol, levonorgestrel and COC. The GnRH agonist binds to the pituitary gland, which is known to down-regulate the P-O axis because it has a longer half-life than the live GnRH. Thus, hypoestrogenism was found to be effective in making endometriosis. However, prolonged use of the GnRH agonist may cause symptoms such as pseudo-menopausal symptoms such as burning of the face, loss of sexual desire, depression, headache, and reduced bone density.
Danazol danazol is effective in treating pain associated with enodmetrosis, but it is not well used due to androgenic side effects (acne, edema, weight gain, hair growth, etc.). Danazol blocks the surge of LH hormone and increases the level of free testosterone due to the steroidogenesis effect. This mechanism inhibits the secretion of GnRH, inhibits the production of ovarian hormone, and prevents the growth of endometriotic tissue.
Aromatase inhibitor aromatase inhibitor is used for patients with severe or refractory endometriosis. Aromatase inhibitor inhibited the formation of local estrogen and inhibited estrogen formation in the ovary or peripheral region. Aromatase inhibitors, however, can have serious side effects such as bone loss and are not well used because ovarian follicular cysts can develop.
Surgical Treatment of Endometriosis
An indication of surgical treatment of endometriosis is a persistent pain complaint and should be performed if the pain is not corrected by medical treatment. It also causes anatomic abnormality due to endometriosis and is performed when it is necessary to surgically correct it.
Usually, the operation is performed through the laparoscope. When the operation is performed, a common gun shot pattern is observed, and a mass of chocolate is observed.
Surgery can be used to establish the stage of endometriosis.
Medical treatment of endometriosis includes NSAIDs, hormonal contraceptives, GnRH agonists, danazol, and aromatase inhibitors. The choice of treatment depends on the severity of the symptoms, the patient's preference, the side effects of the drug, and the efficacy of the treatment.
NSAIDs NSAIDs are effective treatments for menstrual overeating. It is also often used as a primary treatment for pelvic pain. However, NSAIDs do not have a higher efficacy in treating pain due to endometriosis than other agents.
Estrogen-progestin contraceptives Complex contraceptives are used as a primary treatment for endometriosis-related pain because they are long-lasting, relatively cheap, and easy to use. It is often used because it has the effect of lowering the risk of ovarian cancer and endometrial cancer. Combination contraceptives inhibit the function of the ovary, thereby reducing the activity of endometriosis and reducing pain.
GnRH agonist GnRH agonist is known to be more effective than placebo, and it is known that pain relief is greater than danazol, levonorgestrel and COC. The GnRH agonist binds to the pituitary gland, which is known to down-regulate the P-O axis because it has a longer half-life than the live GnRH. Thus, hypoestrogenism was found to be effective in making endometriosis. However, prolonged use of the GnRH agonist may cause symptoms such as pseudo-menopausal symptoms such as burning of the face, loss of sexual desire, depression, headache, and reduced bone density.
Danazol danazol is effective in treating pain associated with enodmetrosis, but it is not well used due to androgenic side effects (acne, edema, weight gain, hair growth, etc.). Danazol blocks the surge of LH hormone and increases the level of free testosterone due to the steroidogenesis effect. This mechanism inhibits the secretion of GnRH, inhibits the production of ovarian hormone, and prevents the growth of endometriotic tissue.
Aromatase inhibitor aromatase inhibitor is used for patients with severe or refractory endometriosis. Aromatase inhibitor inhibited the formation of local estrogen and inhibited estrogen formation in the ovary or peripheral region. Aromatase inhibitors, however, can have serious side effects such as bone loss and are not well used because ovarian follicular cysts can develop.
Surgical Treatment of Endometriosis
An indication of surgical treatment of endometriosis is a persistent pain complaint and should be performed if the pain is not corrected by medical treatment. It also causes anatomic abnormality due to endometriosis and is performed when it is necessary to surgically correct it.
Usually, the operation is performed through the laparoscope. When the operation is performed, a common gun shot pattern is observed, and a mass of chocolate is observed.
Surgery can be used to establish the stage of endometriosis.
